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Original Research Article

Immune response of standard and delayed hepatitis B vaccination schedules among medical students – a cross sectional comparative study

Ansiya A* and M P Saraswathy

Assistant Professor, Dept. of Microbiology, CRRI, ESIC Medical College & PGIMSR, KK Nagar,Chennai

Ind.J.Applied.Microbiol. 2019 .22(1) : 20-30

*Corresponding author


 Context: Health care professionals including medical students face a high risk for  Hepatitis B transmission. Hepatitis B vaccination is routinely administered to health care  providers and medical students. However due to the rigors of medical training, medical students  miss doses of the vaccine. There is scant research on immune response following delayed  immunization schedule. Aims: To compare immune response as measured by anti-HBsAg  antibody levels in medical students who followed delayed and standard vaccination schedule of  Hepatitis B vaccination. Settings and designs: A cross sectional comparative study was  conducted among randomly selected 50 medical students of a medical college in Chennai.  Methods and Materials: Data on demographics, Hepatitis B immunization details and other  covariants were collected. A two step immunoassay, using Chemiluminescent Microparticle  Immunoassay (CMIA) technology was used for the quantitative determination of anti-HBs in  human serum and plasma. The collected data was analyzed using statistical software IBM SPSS  Statistical Package version 21. Results: Of the students, 36 (72%) were females and 14 (28%)  were males. Among the participants who followed standard immunization schedule without delay,  6.3% had poor immune response, and 12.5% were hypo-responsive. Among the participants who  followed delayed schedule, 2.9% were non-responsive and 5.9% were hypo-responsive. After  adjusting for age, gender, BMI and delay in schedule, it was found that greater gap between dose  1 and dose 2(p = 0.001) and gap between dose 2 and dose 3(p = 0.004) significantly influenced  the anti-HBsAg antibody titres. Conclusion: It is seen that a delayed or altered vaccination  schedule did not seriously affect the immune response among medical students. Therefore, the   focus should be on completing the immunization schedule of Hepatitis B at the best available  opportunity. 

Keywords: hepatitis B Vaccination, Immunization schedule, Anti-HBsAg titre, Immune response, Delayed schedule.

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