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R .Gopinath and Elanchezhiyan Manickan*
Department of Microbiology, Dr. ALM PG IBMS, University of Madras, Taramani,Chennai, India.
Ind.J.Applied.Microbiol. 2017 .20(2) : 109-118
One third of the humans are exposed to Mycobacterium tuberculosis (MTB) of which 5- 10% becomes latently infected without symptoms and this predominantly occurs in the early in the life. Of this population about 10% population lead to much aggravated active TB which is the cause for the morbidity and mortality associated with TB. TB is curable upon proper treatment but there is a growing concern over the emergence of MDR and XDR drug resistant MTB. This high degree of resistance and adverse side-effects warrants alternative method of treatment such as traditional medicine systems of Indian subcontinent. Unfortunately such anti TB drugs is not available in the pipeline of alternative medicine systems. In spite of various obstacles that anti MTB allopathic medicines face it stays as main stream because these drugs undergo rigorous scientific testing and evidence based selection. In contrast drugs from traditional medicine system are not backed by such evidence-based scientific testing. It is perhaps the major setback for traditional medicines rather than the perception of aura of modern medicine eclipsing over traditional system of medicines. Unless there is a revolution occurs in the discussed biomedical issues in this review the chances of using traditional medicines as sole treatment method may remain on the horizon.
Keywords: Mycobacterium tuberculosis, Medicinal Plants, Drug Resistant, MDR and XDR-TB, Anti-tubercular, Natural, Ayurveda. , Unani, Surrogate, GeneXpert, BSL-3.
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